李钰皓

发布时间:2021-09-13 浏览次数:10

 

李钰皓

职称

副教授

任职

导师类型

博士生导师(特聘)

所属学科专业

应用化学

电话

 

邮箱

yhli@usst.edu.cn

一、学习工作经历

2021.07-至今  

上海理工大学材料与化学学院

副教授/博士生导师

2018.06-2021.06

上海理工大学理学院

副教授/博士生导师

2017.06-2018.06

上海理工大学理学院

讲师/硕士生导师

2015.04-2017.06

上海理工大学理学院

师资博士后

2012.08-2015.04

复旦大学化学系

博士后

2011.08-2012.08

美国北达科他州州立大学化学系

博士后

2006.09-2011.09

南京工业大学理学院

应用化学/博士

2004.09-2006.09

南京晓庄学院化学系

分析技术/学士

二、研究方向

1)有机无机纳米复合材料的生物传感与智能诊疗应用;

2)有机光功能材料。

三、科研成果

主要研究方向为有机无机纳米复合材料的生物传感与智能诊疗应用;有机光功能材料包括非线性光学材料、光致发光材料、化学传感材料等。主持国家自然科学基金项目、上海市自然科学基金、中国博士后科学基金等。共在《Journal of American Chemical Society》、《Small》、《ACS Applied Materials & Interfaces》、《Acta   Biomaterialia》等国内外杂志发表学术论文50余篇申请国家发明专利5项,已授权2项。

代表性项目:

1)上海市自然科学基金面上项目(19ZR1434700

2)国家自然科学基金青年项目   21501121

3)中国博士后科学基金特别项目(2016T90376

代表性科研论文:

2021

(1)    Jing   Zhang, Kang Song, Yun Sun,* Yuqing Miao,* Yuhao Li*, et al.   Biodegradable Bismuth–Gadolinium-Based Nano Contrast Agent for Accurate   Identification and Imaging of Renal Insufficiency In Vivo, Inorg.   Chem. Front., 2021, DOI: 10.1039/D1QI00878A.

(2)    Jie   Liu, Jing Zhang, Yuqing Miao, Yun Sun,* Yuhao Li*, et al. Tumor   Microenvironment Modulation Platform Based on Composite Biodegradable   Bismuth–Manganese Radiosensitizer for Inhibiting Radioresistant Hypoxic   Tumors, Small, 2021, DOI:10.1002/smll.202101015.

(3)    Fei   Huang, Yuhao Li*, Yuqing Miao, Yun Sun*, et al. Intraperitoneal   Injection of Cyanine-Based Nanomicelles for Enhanced Near-Infrared   Fluorescence Imaging and Surgical Navigation in Abdominal Tumors, ACS   Appl. Bio Mater., 2021, 4, 5695-5706.

(4)    Yongtian   Liu, Jing Zhang, Yuqing Miao, Yun Sun*, Yuhao Li*, et al.   Biodegradable BiOCl Platform for Oxidative Stress Injury–Enhanced   Chemodynamic/Radiation Therapy of Hypoxic Tumors, Acta Biomater., 2021,   129, 280-292.

(5)    Yao   Xu, Yuqing Miao, Yuhao Li*, et al. BSA-encapsulated cyclometalated   iridium complexes as nano-photosensitizers for photodynamic therapy of tumor   cells, RSC Advances, 2021, 11, 15323-15331.

(6)    Yong   Deng, Yun Sun*, Yuhao Li*, et al. Dual-light triggered metabolizable   nano-micelles for selective tumor-targeted photodynamic/hyperthermia therapy,   Acta   Biomater., 2021, 119, 323-336.

2020

(7)    Jing   Zhang, Yun Sun*, Yuhao Li*, et al.   Nanozyme-incorporated biodegradable bismuth mesoporous radiosensitizer for   tumor microenvironment-modulated hypoxic tumor thermoradiotherapy, ACS   Appl. Mater. Interfaces, 2020, 12, 57768-57781.

(8)    Jie   Liu, Yun Sun*, Yuhao Li*, et al. X-ray and NIR light dual-triggered   mesoporous upconversion nanophosphor/Bi heterojunction radiosensitizer for   highly efficient tumor ablation, Acta Biomater., 2020, 113,   570-583.

(9)    Guangcong   Zhang, Jie Liu, Jimin Zhu*, Shuqiang Wen*, Yuhao Li*, et al.   Bismuth-based mesoporous nanoball carrying sorafenib for computed tomography   imaging and synergetic chemoradiotherapy of hepatocellular carcinoma, Adv.   Healthc. Mater., 2020, 2000650.

(10)              Xiaojia Qin, Jie Liu, Yuhao Li*,   Yingjian Zhang, Yun Sun*, et al. Mesoporous Bi-containing radiosensitizer   loading with DOX to repolarize tumor-associated macrophages and elicit   immunogenic tumor cell death to inhibit tumor progression, ACS   Appl. Mater. Interfaces, 2020, 12, 31225-31234.

(11)              Yong Deng, Yun Sun*, Yuhao Li*, et   al. PEGylated iridium-based nano-micelle: Self-assembly, selective tumor   fluorescence imaging and photodynamic therapy, Dyes Pigments, 2020,   182, 108651.

(12)              Xiangnan Yu, Yong Deng,Yuhao Li*, Jimin Zhu*, et al. Sorafenib-conjugated zinc   phthalocyanine-based nanocapsule for trimodal therapy in an orthotopic   hepatocellular carcinoma xenograft mouse model, ACS Appl. Mater. Interfaces,   2020, 12, 17193-17206.

(13)              Yong Deng, Yun Sun*, Yuhao Li*, et   al. Electrostatic self-assembled iridium(III) nano-photosensitizer for   selectively disintegrated and mitochondria targeted photodynamic therapy, Dyes   Pigments, 2020, 175, 108105.

2019

(14)              Jie Liu, Yuhao Li*, Yuqing Miao*   and Yun Sun*, et al. Ultrafast synthesizing bismuth mesoporous nanolitchi   radiosensitizer loading high dose DOX for CT-guided enhanced   chemoradiotherapy, ACS Appl. Mater. Interfaces, 2019,   11, 42932-42942. (Cover paper)

(15)              Yuhao Li, Jie Liu, Yun Sun*, et al.   Ultrafast synthesis of fluorine-18 doped bismuth based upconversion   nanophosphors for tri-modal CT/PET/UCL imaging in vivo, Chem. Commun., 2019,   55, 7259-7262.

(16)              Yuhao Li*,   Yuqing Miao, et al. A near-infrared frequency upconversion probe for nitroreductase   detection and hypoxia tumor in vivo imaging, Sensor. Actuat. B Chem.,   2019, 286, 337-345.

(17)              Yuhao Li*, Yuqing Miao, et al. An   AEE-active probe combined with cyanoacrylate fuming for a high resolution   fingermark optical detection, Sensor. Actuat. B Chem., 2019,   283, 99-106.

2017

(18)              Yuhao Li*, Yun Sun*, Yuqing Miao,   et al. A cation-exchange controlled core-shell MnS@Bi2S3   theranostic platform for multimodal imaging guided radiation therapy with   hyperthermia boost, Nanoscale, 2017, 9, 14364-14375. (Back cover paper)

(19)              Yuhao Li*, Rui Liu*, Yuqing Miao*,   et al. SiO2 encapsulated nanofluorophor: photophysical properties,   aggregation induced emission and its application for cell mitochondria   imaging, Dyes Pigments, 2017, 139, 110-117.

Before   2017

(20)              Yuhao Li*, Yuqing Miao*, et al.   NiCoP Nanoparticles as efficient electrocatalyst for oxygen evolution   reaction in an alkaline solution, Int. J. Electrochem. Sci., 2016,   11, 9917-9927.

(21)              Yuhao Li, Wei Feng*, Fuyou Li*, et   al. Ultrasensitive near-infrared fluorescence-enhanced probe for in vivo   nitroreductase imaging, J. Am. Chem. Soc., 2015, 137 (19),   6407-6416. (ESI高被引论文)

(22)              Yuhao Li, Wenfang Sun*, et al.   Effects of extended π-conjugation in phenanthroline (N^N) and phenylpyridine   (C^N) ligands on the photophysics and reverse saturable absorption of   cationic heteroleptic iridium(III) complexes, J. Phys. Chem. C, 2014,   118, 6372-6384.

(23)              Yuhao Li, Wenfang Sun*, et al. Synthesis   and photophysics of reverse saturable absorbing heteroleptic iridium(III)   complexes bearing 2-(7-r-fluoren-2'-yl)pyridine ligands, Dalton   Trans.,   2014, 43, 1724-1735.

(24)              Yuhao Li,   Rui Liu*, Fuyou Li*, et al. A bioprobe based on aggregation induced emission (AIE) for cell   membrane tracking, Chem. Commun., 2013, 49, 11335-11337.

(25)              Yuhao Li,   Wenfang Sun*, et   al. Nonlinear absorbing cationic   iridium(III) complexes bearing benzothiazolylfluorene motif on the bipyridine   (N^N) ligand: synthesis,   photophysics and reverse saturable absorption, ACS Appl. Mater. Interfaces, 2013, 5, 6556-6570.

(26)              Yuhao Li,   Wenfang Sun*, et   al. Long-lived π-shape platinum(II)   diimine complexes bearing 7-benzothiazolylfluoren-2-yl motif on the   bipyridine and acetylide ligands: admixing π,π* and charge transfer configurations,   J. Phys. Chem. C,   2013, 117, 5908-5918.

(27)              Yuhao Li,   Hongjun Zhu*, et   al. Synthesis, Insecticidal activity,   and structure-activity relationship (SAR) of anthranilic diamides analogous   containing oxadiazole ring, Org. Biomol. Chem., 2013, 11, 3979-3988.

四、学术任职

现任上海市药学会生化与生物技术药物专业委员会委员、上海市生物医学工程学会智慧医学诊断专业委员会委员。担任多种学术期刊杂志审稿人。

五、授课情况

主讲本科生课程《有机化学》、《有机合成》、《分析化学》、《普通化学实验》、《有机化学实验》、《分析化学实验》等;研究生课程《绿色能源化学》、《光学成像与分析》。

六、获奖情况

1)上海市高校青年教师教学竞赛三等奖(2020

2)上海理工大学教学技能竞赛二等奖(2020

3)上海理工大学青年教师教学竞赛二等奖(2018